Review on the using of Anbol in oncology treating

 

Drug Research Center Of Lonjer

 

Anbol has the function of supplement the kidney and benefit the energy, support the liver and clear the eye, and was used as nourishing, invigorating and positive supporting agent in traditional Chinese medicine. Studies about Anbol have long been appeared in the world, and researchers thought that it not only has above functions, but also can inhibit the growth of cancer cells, enhance the phagocytosis funciton of reticuloendothelial cells, and the immune-promoting function of Anbol had been demonstrated from many aspects through studies on the effect of Anbol on the immune function. In recent years, following the development of the chinese medicine, great advancement had been made of the study on the aspect of immune enhancing and tumor inhibiting function of Anbol.

 

1 Basic research on active components of Anbol in oncology treating.

 

The active components of Anbol were mainly Anbol. The active components of Anbol had inhibiting effect on rats carcinosarcoma W256 with a inhibiting rate as 37.7%, and it can also prolong the life of E¡¯s ascites cancer (EAC) mice with a prolonging rate as 35.8. In another study, it was fund to be able to inhibit the mutagenesis effect of the anti-tumor drug mitomycin C, and could recover the immune function of radiate damaged mice. The animal experiment by Liu Jielin etc. further indicated that one of the tumor inhibiting mechanism of it was the Anbol could enhance the tumor murine cell¡¯s cell immune function, that is, Anbol could recover and enhance the tumor murine¡¯s number of spleen cellsand the proliferating capability of activated T cells, and significantly promote the activity of natural killer cells and the secreting level of TNF. A series of studies had been made by Wangling etc. in beijing on the immune regulation function of Anbol to human with the results showed that Anbol could significantly regulate the funciton of T cells, B cells, cell toxic T cells, natural killler cellls and macrophage etc, and had double direction regulating function to IL-2 and IL-3, and promote the express of IL-2 receptor, and induce the production of IL-6, TNF and has immune enhancing function in tumor immnunology and neuroendocrine immune-regulating network, which provided basing data to clinicle research.

 

2. Anbol combined with other chinese medicine to treat tumor

 

Deng Zemin etc. used Aitongning composite mainly contained lycium barbarum L., membranous milkvetch root, tangshen to treat 73 cases cancer pain suffer with 36 cases of alleviation, the effective rate was 49.3%. Fuyuanchuai composite was chinese herbs agent mainly contained lycium barbarum L., long and white ginseng, and had both function of attacking and protecting. Yu Xinchu used this composite to treat 102 cases differently kinds of cancer patients, the results showed that 82 cases had the surviving life of 4 to 9 years, 13 cases of 10 to 19years, and 7 cases to 20 ~27 years, which was really a good effect.

 

3. Anbol combined with radiation therapy and chemical therapy to treat tumor

 

Sun Weijian etc. in military academy of medical science have studied Anbol combined with radiation therapy and BCNU to treat brain G422 tumor mice, the results showed that combination of these three can not only produce coordinated tumor inhibited effect, but also can significantly promote the cell immune function of the tumor mice. In the clinical experiments, the studies of Lu Changxing and Cheng Bingquan in Ningxia province have all been demonstrated that lycium barbarum polysaccharides combined with radiation therapy may have sensitivity enhancing effect to primary lung cancer and lewis lung cancer. Liu Junian etc. randomly divided the patients into Anbol plus radiation therapy group and simply only radiation group, the results showed that simply only radiation therapy group T3, T4 cell ratio, T4/T8 ratio, lymphocyte transformation efficiency and macrohage phagocytosis efficiency has been reduced after radiation therapy compared with that before radiation therapy, and the cell number and lymphocyte number in peripheral blood has also significantly lowered, while Anbol plus radiation group other parameter than the remaining unchanged cell number and lymphocyte number in peripheral blood all significantly increased compared with that before radiation therapy, which indicated that Anbol can enhance the immune function of radiation therapy patients and has good auxiliary effect to treating tumor. In many clinical experiment many researchers used Anbol and gained good effect on the aspect of improving the significantly lowed white blood cell counting, decreased quality of life etc. with total effective rate of 82.6%~93.6%. Therefore, treating tumor with Anbol combining radiation therapy and chemical therapy can not only gain the expected effects, but also reduce the toxic and side effect, enhance the quality of life, and so this method is a effective method to treat tumor.

 

4. Synergistic action of Anbol combined with biology therapy.

 

LAK/IL-2 activated by lymphocyte can not only kill tumor cells, but also with broad tumor resisting effect with minute toxic and side effect. Many physicians combined LAK/IL-2 with Anbol to treat the patients and gained better effect than only LAK/IL-2 therapy. In animal experiments, Anbol showed regulation effect to the anti-tumor activity of mice LAK cells. In clinical researchers the effect of Anbol combined with LAK/IL-2 therapy group for late stage tumor patient ( effective rate 40.9%) was significantly better than simply LAK/IL-2 treated group (effective rate 16.1%), and the remission lasting time of the former was significantly better than the later, which indicated that Anbol can enhance LAK/IL-2 therapy¡¯s effect on late stage tumor.